Observations on nitroxyl free radicals in arylamine carcinogenesis and on spin-trapping hydroxyl free radicals
نویسندگان
چکیده
منابع مشابه
Free radicals in carcinogenesis.
It has become clear since the workshop that free radicals are implicated not only in the promotion phase of carcinogenesis but during initiation as well. Since the workshop, however, despite intriguing trapping studies with Superoxide disimilase. catalase, and Cu-DIPS [copper(II)(3,5-diisopropylsalicylate)2] and generation of OJ using xanthine oxidase, little substantive evidence has been obtai...
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In an ESR spin-trapping measurement of hydroxyl radicals formed in a Fenton reaction, the trapping efficiency with DMPO increased by about 300 times in a sodium trifluoroacetate solution, whereas it was little changed in a phosphate buffer.
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Additional experimental evidence is presented for in vitro generation of hydroxyl radicals because of redox cycling of environmentally persistent free radicals (EPFRs) produced after adsorption of 2-monochlorophenol at 230 °C (2-MCP-230) on copper oxide supported by silica, 5% Cu(II)O/silica (3.9% Cu). A chemical spin trapping agent, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), in conjunction with ...
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Biomolecule-centered radicals are intermediate species produced during both reversible (redox modulation) and irreversible (oxidative stress) oxidative modification of biomolecules. These oxidative processes must be studied in situ and in real time to understand the molecular mechanism of cell adaptation or death in response to changes in the extracellular environment. In this regard, we have d...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1982
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v82-506